Endocrine Abstracts

It is known that disoaders of the hypothalamic-pituitary-adrenal system and excess glucocorticoids in Cushing’s disease (CD) can significantly affect various organs and systems, in particular, the secretion of pituitary hormones. However, in the literature there is practically no work on the assessment of the state of tropic hormones and hormones of the peripheral glands in the early postoperative period after transsphenoidal adenomectomy. The aim of this study was to ass...

Aim: To access the efficiency of mulitispine computed tomography (MSCT) in ectopic ACTH-syndrome.Patients and methods: Five clinical cases (2 female and 3 male cases) with severe hypercortisolism were analyzed, age from 26 to 63 years old.Results: In all of the 5 cases there were significant reasons to suppose ectopic ACTH-syndrome: rapid development of clinical features (in 4 of 5 cases), loss of lean mass compound with rounded an...

Objective: To analyze long-term treatment outcomes and to determine prognostic factors affecting the survival of patients with ECS. Matherials and methods: Retrospective, observational study on 147 patients (88 women, 59 men) with ECS diagnosed between 1990 and 2021. Various imaging studies were performed on all patients to find the source of ACTH producing neuroendocrine tumor (NET). Multivariable analysis was performed using a Cox proportional hazards ...

Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after.The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent CD in the active stage (disease duration up to 3 years). Before neurosurgery blood ACTH (median...

Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing’s disease (CD).Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing’s syndrome (CS) (159 CD, 21 ACTH-ectopic syndrome) were compared according to the cause of hypercortisolism. ROC-ana...

BackgroundEctopic ACTH syndrome (EAS) is a rare cause of endogenous hypercortisolism.ObjectiveTo analyze clinical, biochemical features and treatment outcomes of patients with EAS.Materials and methodsRetrospective, observational study on 129 patients (79 women, 50 men) with EAS diagnosed between 1990 and 2020. Plasma levels of ACTH (reference range: morning 7.2&#...

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

BackgroundPituitary disease registries are major instruments of epidemiological and clinical data collection used worldwide.ObjectiveTo assess the data of pituitary tumor registry in Russia.Material and methodsPatient records, retrieved from online platform of the Registry.ResultsCurrently there are 9858 patients regis...

IntroductionSARS-CoV-2 has caused a global outbreak of coronavirus disease 2019 (COVID-19). It is known that this virus binds angiotensin-converting enzyme 2 (ACE2) of the renin-angiotensin system, which may exert substantial effects on sodium and potassium metabolism. Viral pneumonia and respiratory distress are well known etiologies for hyponatremia due to syndrome of inadequate secretion of antidiuretic hormone, and can worsen clinical course of the d...